 today announced that its proprietary large-language model (LLM) scored 96% on a validated set of United States Medical Licensing Examination (USMLE) questions, the highest accuracy yet reported for a specialized medical AI. The result strengthens Pathway’s position as a leading evidence-based decision-support tool for frontline clinicians.

In head-to-head testing, Pathway’s “Deep” AI model surpassed domain-specific peers MediSearch Pro, OpenEvidence and Hippocratic AI, and outperformed generalist systems such as ChatGPT 4o, o1, and GPT-4.5 on complex diagnostic scenarios. Independent academic validation studies are currently underway to further corroborate these groundbreaking results.

Pathway attributes the performance to its transparent just-in-time reasoning pipeline, which combines retrieval-augmented generation (RAG) with chain-of-thought (CoT) analysis and agentic tool calling. The architecture allows the model to evaluate multiple information sources simultaneously, surface potential knowledge gaps, generate follow-up questions, and apply clinical scoring and prediction rules—all without adding latency for the user.

“Trust and transparency are foundational for bringing AI into clinical workflows,” said Dr. Louis Mullie, Chief Medical Officer at Pathway. “Clinicians need speed and accuracy, but they also need verifiable evidence. Pathway’s assistant reveals its reasoning step-by-step and links every recommendation to expert-vetted guidelines and a comprehensive drug reference. By giving users the context to double-check dosages and key guidance, Pathway helps them leverage AI efficiently while maintaining full control over patient-safety decisions.”

This milestone builds on Pathway’s rapid growth and industry recognition. In 2024 Pathway became the first generative-AI medical tool to receive continuing-medical-education (CME) co-accreditation, making every clinical question asked through the platform eligible for CME credit. Earlier this year the company added HIPAA support for Pathway Plus subscribers, enabling secure, compliant integration of patient-specific data into AI queries. Pathway also recently surpassed one million registered users across more than 10,000 healthcare institutions, underscoring its widespread adoption and trust within the medical community.

Pathway helps clinicians deliver better, faster, safer care by providing instant, evidence-based answers to medical questions. With 1 million+ registered healthcare professionals spanning 10,000 care centers, the AI-powered platform has established a strong presence across the United States and internationally.

Pathway sets a new benchmark for specialty medical AI

We're excited to announce that HIPAA-compliance is now available on 

, you can include real patient details in your Pathway AI prompts while staying compliant and ensuring patient privacy.

HIPAA compliance is automatically enabled on web for Pathway Plus subscribers. To enable it on your mobile device, please make sure you’ve updated to the latest version of the Pathway app and that you have a Pathway Plus subscription.

We’re committed to building generative AI that truly supports clinicians and is designed for the specific demands of clinical practice.

That means clear and transparent referencing, high-quality evidence, advanced clinical reasoning, CME accreditation, and now, HIPAA compliance.


There’s more to come, and we appreciate the users who help guide what we build. If you have any questions or feedback, just reply to this email—we’d love to hear from you.

Enjoy,
The Pathway Team

Introducing HIPAA Compliance

We’re excited to share some major updates—Pathway just got faster, smarter, and even more accessible.

We recently crossed 

, and we’ve been hard at work improving every part of the experience. You can try these updates now on 

The first reasoning model built for medicine



We launched a first-of-its-kind reasoning model for medicine—Pathway now thinks like a colleague, breaking down answers step by step, diving deeper into complex cases, and providing more detailed reasoning when needed.



Now one of the fastest reasoning models available



Speed matters. We just rolled out a 2x speed improvement and 1.5x lower latency, making Pathway one of the fastest reasoning models out there—and it’s only getting faster.





Need an answer but don’t have time to read? Now, Pathway can read responses aloud, so you can listen while you work, drive, or move between patients. It turns any question into an on-demand podcast.





Ask for a score, enter patient details, and Pathway will calculate it and generate a full interactive calculator so you can adjust inputs in real time.





Just ask, and Pathway will structure key details into a table for quick reference.





Pathway now displays structured drug cards for precise dosing, modifications, and interactions, so you can quickly double-check before prescribing.



Making medical knowledge easier to access



Medical knowledge should be open, not locked behind paywalls. That’s why we’ve expanded free access:

• 10 free AI questions per day
• Unlimited follow-up questions
• AI chat history
• Full access to guideline summaries, study summaries, and drug info

Most of Pathway is now free for everyday clinical use.

Pathway Plus subscribers still get unlimited Pathway AI, unlimited CME redemption, no ads, and soon, access to even more advanced reasoning models.





You can now ask questions in over 50 languages, making Pathway even more accessible to clinicians worldwide.





Pathway now supports patient counseling guidance, clinical note generation, medical quizzes, and differential diagnosis support—helping you work more efficiently.



The only AI tool for medicine with built-in CME



We remain the only AMA PRA Category 1™ CME-accredited AI tool for medicine. Every question you ask earns CME.

Our latest updates are live: try them today on 

Major updates to Pathway

We’re excited to share that Pathway is now 

the first and only generative AI solution purpose‑built for medicine to earn CME accreditation

CME credit is available today on both the web and mobile versions of Pathway AI, so you can learn and log credit wherever you practice.

Pathway’s mission is to support clinical reasoning with transparent, high‑quality AI. Adding CME is the next step in making your everyday questions count toward lifelong learning. Update your app, try it on your next case, and turn curiosity into credentialed expertise, without adding minutes to your day.

Have feedback or feature requests? Let us know at support@pathway.md.

Introducing CME for Pathway AI

A few weeks ago, Pathway became the first generative AI tool for medicine that not only shows references, but also its reasoning process.


Today, we’re taking it one step further.

Pathway’s new Reasoning Mode pulls from more references, breaks down complex questions step by step, self-critiques in real-time, and shows you its 

 thought process.

Unlike general AI tools that take extra time to reason through complex questions, Pathway’s Reasoning Mode does this 

, so you get deeper insights instantly, without slowing you down.


Pathway is now more accurate, more transparent, and smarter than ever, especially for tricky clinical cases where standard AI responses can fall short.

Plus users have unlimited access to Reasoning Mode, while free users can access five Reasoning Mode questions per day.

And it’s now live. Try it today on 

Introducing Reasoning Mode

Pathway AI integrates physician‑reviewed, evidence‑based literature with advanced large‑language‑model technology to support clinicians in making timely, well‑informed decisions across a broad range of medical topics. While the platform aims for high accuracy, it is intended solely as an auxiliary resource. Professional judgement remains essential, and all information obtained through Pathway AI should be independently verified before application in patient care.


Because Pathway AI is still in beta, its functionality and reliability continue to evolve. Users should treat the system as they would a clinician in training, reviewing its outputs carefully and confirming any recommendations prior to clinical use. To safeguard patient privacy, please refrain from entering personally identifiable health information into the platform.


Your feedback is vital to our ongoing improvements. If you encounter issues, notice inaccuracies, or have suggestions, we encourage you to share them through the usual channels. By using Pathway AI, you acknowledge these limitations and guidelines. We appreciate your partnership as we refine this tool to better serve the clinical community.

Introducing Pathway AI

Today, I’m thrilled to announce Pathway's $5 million seed funding round. This marks a significant step towards our mission to make evidence-based medical knowledge more accessible and integrated into clinical practice worldwide.


Clinicians are facing the most overwhelming increase in medical information in history. Medical knowledge 

 roughly every 73 days, with ongoing clinical studies ballooning from 

 2,000 in 2000 to nearly 454,000 in 2023. In biomedicine alone, 

 1 million articles are published on PubMed annually – roughly 2 papers per minute. This surge 

 to overwhelming rates of burnout and depression in healthcare professionals, to say nothing of the fact that an estimated 45% of patients 

It’s clear that the exponential growth of medical data outpaces traditional, linear methods of managing it, leaving modern clinicians, who expect instant, seamless information, struggling to keep up.

Pathway is designed to help clinicians handle the ever-increasing volume of medical information. By leveraging advanced technology, including generative AI, we're building a better way to organize and present vast amounts of complex medical data. Our goal is to ensure clinicians can easily access up-to-date information without feeling overwhelmed, so they can offer the best possible care to their patients.

Why did we start Pathway? Because we know firsthand how acute the problem of managing medical information is. During his Internal Medicine residency, our co-founder 

 began by creating summaries of key medical guidelines. These summaries were the foundation of our initial app, GuidelineMD, which rapidly gained popularity among doctors.

Facing the need to scale content production, we encountered a bottleneck. With one clinician on the team and little funding, we couldn't match our main competitor, who employed over 7000 authors and editors. This challenge required a better "machine behind the machine" to aggregate data, leading to the birth of Pathway and its underlying technology.

Pathway has grown significantly since, largely due to the incredible feedback and support from a global clinical community. This has resulted in over 370,000 clinicians from 200 countries registering on our platform, many of whom are in the United States. Thousands of clinicians are choosing our premium product over free options, showing just how much value Pathway provides. The platform now offers over 70,000 recommendations on 30,000 clinical topics and is becoming a default clinical co-pilot for healthcare professionals worldwide.

This funding will help us to refine Pathway's user experience, introduce features that respond directly to our users' needs, and broaden our reach to support clinicians globally. Our commitment is to continually evolve based on user feedback, ensuring every clinician using Pathway has the tools and information they need to provide exceptional care, regardless of location.

 in a limited beta. This tool combines the power of generative AI with our extensive, physician-vetted medical knowledge graph, delivering accurate, referenced answers to clinical queries. While it's currently available to verified clinicians in the US, we plan to expand its availability soon.

In our pursuit of accessibility, we've opened up more of Pathway's content for free. Our goal is to provide unrestricted access to evidence-based information to all, regardless of location or background. Existing Pathway Plus subscribers still get access to premium content and features and priority access to Pathway AI beta. We'll be releasing more updates on this soon.

We have many more exciting announcements planned over the coming months, so stay tuned.

, with participation from existing investors 

We’re also excited to have the backing of several physicians who have experienced the transformative potential of Pathway firsthand.


We're thankful to our investors, team, and clinician community for their trust and support, which drives us daily to make healthcare knowledge more accessible and actionable. We’re dedicated to spending the next decade and beyond improving this platform as we push the boundaries of clinical support tools, making clinicians worldwide more efficient, and helping patients globally get access to the best possible care.

News and Updates

Pathway sets a new benchmark for specialty medical AI

Introducing HIPAA Compliance

Major updates to Pathway

Introducing CME for Pathway AI

Introducing Reasoning Mode

Introducing Pathway AI

Pathway raises a $5M seed to empower clinicians

News and Updates

Pathway sets a new benchmark for specialty medical AI

Introducing HIPAA Compliance

Major updates to Pathway

Introducing CME for Pathway AI

Introducing Reasoning Mode

Introducing Pathway AI

Pathway raises a $5M seed to empower clinicians

Introducing CME for Pathway AI