TTH48
Trial question
What is the role of prolonged targeted temperature management in survivors of out-of-hospital cardiac arrest?
Study design
Multi-center
Open label
RCT
Population
Characteristics of study participants
10.0% female
90.0% male
N = 79
79 patients (8 female, 71 male)
Inclusion criteria: out-of-hospital cardiac arrest survivors with perceived good cognitive outcome
Key exclusion criteria: out-of-hospital cardiac arrest of suspected origin other than cardiac, in-hospital cardiac arrest, terminal disease, coagulation disorders, unwitnessed asystolia
Interventions
N=43 TTM48 (prolonged target temperature management for 48 hours)
N=36 TTM24 (standard targeted temperature management for 24 hours)
Primary outcome
Cognitive impairment at 6 months
12
33
33.0 %
24.8 %
16.5 %
8.3 %
0.0 %
TTM48
TTM24
Significant
increase ▲
NNH = 4
Significant increase in cognitive impairment at 6 months (12% vs. 33%; RR 2.9, 95% CI 1.1 to 7.4)
Safety outcomes
No significant differences in attention, executive function.
Conclusion
In out-of-hospital cardiac arrest survivors with perceived good cognitive outcome, TTM48 was superior to TTM24 with respect to cognitive impairment at 6 months.
Reference
Lars Evald, Kolbjørn Brønnick, Christophe Henri Valdemar Duez et al. Prolonged targeted temperature management reduces memory retrieval deficits six months post-cardiac arrest: A randomised controlled trial. Resuscitation. 2019 Jan;134:1-9.
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