PARTITA

Trial question

What is the role of ventricular tachycardia ablation in patients with an implantable cardioverter defibrillator?

Study design

Multi-center

Open label

RCT

Population

Characteristics of study participants

15.0% female

85.0% male

N = 47

47 patients (7 female, 40 male)

Inclusion criteria: patients with dilated cardiomyopathy who received implantable cardioverter defibrillator shock for ventricular tachycardia

Key exclusion criteria: contraindication to transcatheter ablation or antithrombotic therapy; chronic treatment with class I or class III antiarrhythmic drug

Interventions

N=23 ablation (ventricular tachycardia ablation within 2 months of the implantable cardioverter defibrillator shock)

N=24 standard therapy (continuation of standard therapy)

Primary outcome

Composite outcome of death from any cause or hospitalization for worsening heart failure

42.0 %

31.5 %

21.0 %

10.5 %

0.0 %

Ablation

Standard therapy

Significant decrease ▼

NNT = 2

Significant decrease in composite outcome of death from any cause or hospitalization for worsening HF (4% vs. 42%; HR 0.11, 95% CI 0.01 to 0.85)

Secondary outcomes

Significant decrease in death from all causes (0% vs. 33%; ARD -33, 95% CI -55.44 to -10.56)

Significant decrease in recurrent ventricular tachycardia with shocks (9% vs. 42%; ARD -33, 95% CI -64.39 to -1.61)

No significant difference in worsening HF hospitalization (4% vs. 17%; ARD -13, 95% CI -31.07 to 5.07)

Conclusion

In patients with dilated cardiomyopathy who received implantable cardioverter defibrillator shock for ventricular tachycardia, ablation was superior to standard therapy with respect to the composite outcome of death from any cause or hospitalization for worsening HF.

Reference

Paolo Della Bella, Francesca Baratto, Pasquale Vergara et al. Does Timing of Ventricular Tachycardia Ablation Affect Prognosis in Patients With an Implantable Cardioverter Defibrillator? Results From the Multicenter Randomized PARTITA Trial. Circulation. 2022 Jun 21;145(25):1829-1838.

Open reference URL

Create free account