m-CCRP
Trial question
What is the role of mobile critical care recovery program in acute respiratory failure survivors?
Study design
Multi-center
Open label
RCT
Population
Characteristics of study participants
54.0% female
46.0% male
N = 466
466 patients (250 female, 216 male).
Inclusion criteria: ICU patients with acute respiratory failure.
Key exclusion criteria: cancer diagnosis with < 1 year life expectancy; acute neurological injury; neurodegenerative illness; hearing loss; legal blindness; pregnancy or lactation; alcohol or substance use disorder; incarceration.
Interventions
N=233 mobile critical care recovery program (a 12-month nurse-led collaborative care intervention including home visits and weekly multidisciplinary team collaborations).
N=233 attention control (telephone-based care coordinator assistance for 12 months).
Primary outcome
36-Item Medical Outcomes Study Short Form Health Survey Physical Component Summary at 12 months
36.22
35.29
36.2
27.2
18.1
9.1
0.0
Mobile critical care recovery
program
Attention
control
No significant
difference ↔
No significant difference in 36-Item Medical Outcomes Study Short Form Health Survey Physical Component Summary at 12 months (36.22 vs. 35.29; AD 1.61 , 95% CI -1.06 to 4.29).
Secondary outcomes
No significant difference in 36-Item Medical Outcomes Study Short Form Health Survey Mental Component Summary at 12 months (49.81 vs. 51.12; AD -2.5 , 95% CI -5.29 to 0.3).
No significant difference in PHQ-9 at 12 months (5.94 vs. 5.66; AD 0.53 , 95% CI -0.8 to 1.86).
No significant difference in GAD-7 at 12 months (5.04 vs. 4.82; AD 0.37 , 95% CI -0.94 to 1.67).
Conclusion
In ICU patients with acute respiratory failure, mobile critical care recovery program was not superior to attention control with respect to a 36-Item Medical Outcomes Study Short Form Health Survey Physical Component Summary at 12 months.
Reference
Babar A Khan, Anthony J Perkins, Sikandar Hayat Khan et al. Mobile Critical Care Recovery Program for Survivors of Acute Respiratory Failure: A Randomized Clinical Trial. JAMA Netw Open. 2024 Jan 2;7(1):e2353158.
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