LAMP
Trial question
What is the effect of adding pulsed xenon UV light disinfection to standard terminal cleaning in reducing environmentally-implicated healthcare-associated infections?
Study design
Multi-center
Double blinded
RCT
Population
Characteristics of study participants
47.5% female
52.5% male
N = 19413
19413 patients (9215 female, 10191 male)
Inclusion criteria: patients who remained in the hospital for ≥ 4 days
Key exclusion criteria: any environmentally-implicated healthcare-associated infections in which the patient had a previous infection with the same organism within previous 14 days
Interventions
N=9117 PX-UV disinfection (pulsed xenon UV disinfection after standard terminal cleaning)
N=10296 sham disinfection (sham disinfection after standard terminal cleaning)
Primary outcome
Environmentally-implicated healthcare-associated infections
3.491
3.171
3.5/1000 pd
2.6/1000 pd
1.7/1000 pd
0.9/1000 pd
0.0/1000 pd
PX-UV
disinfection
Sham
disinfection
No significant
difference ↔
No significant difference in environmentally-implicated healthcare-associated infections (3.491/1000 pd vs. 3.171/1000 pd; RR 1.1, 95% CI 0.94 to 1.29)
Secondary outcomes
No significant difference in device infections (0.431/1000 pd vs. 0.411/1000 pd; RR 1.03, 95% CI 0.65 to 1.65)
No significant difference in catheter-associated UTIs (0.211/1000 pd vs. 0.221/1000 pd; RR 0.95, 95% CI 0.49 to 1.83)
No significant difference in central line-associated bloodstream infection (0.221/1000 pd vs. 0.201/1000 pd; RR 1.13, 95% CI 0.58 to 2.18)
Conclusion
In patients who remained in the hospital for ≥ 4 days, PX-UV disinfection was not superior to sham disinfection with respect to a environmentally-implicated healthcare-associated infections.
Reference
Sorabh Dhar, Chetan Jinadatha, Paul E Kilgore et al. Lowering the Acquisition of Multi-drug Resistant Organism (MDROs) with Pulsed-xenon (LAMP) Study: a cluster randomized controlled, double-blinded, interventional crossover trial. Clin Infect Dis. 2024 May 14:ciae240. Online ahead of print.
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