CATCH
Trial question
What is the role of interprofessional addiction consultation services in hospitalized adults with opioid use disorder?
Study design
Multi-center
Open label
RCT
Population
Characteristics of study participants
27.0% female
73.0% male
N = 2315
2315 patients (628 female, 1687 male).
Inclusion criteria: hospitalized adults with an admission or discharge diagnosis of opioid use disorder.
Key exclusion criteria: dedicated inpatients of psychiatric, detoxification, or prison units; Medicaid claim for medications for opioid use disorder 30 days before hospitalization; dual services of both Medicaid and Medicare.
Interventions
N=1895 addiction consultation service (interprofessional addiction consultation services provided during hospitalization).
N=1330 usual care (treatment as usual).
Primary outcome
Rate of initiation of medication for opioid use disorder in the first 14 days after hospital discharge
11%
6.7%
11.0 %
8.3 %
5.5 %
2.8 %
0.0 %
Addiction consultation
service
Usual
care
Significant
increase ▲
NNT = 23
Significant increase in the rate of initiation of medication for opioid use disorder in the first 14 days after hospital discharge (11% vs. 6.7%; OR 7.96, 96% CI 1.67 to 54.71).
Secondary outcomes
No significant difference in the rate of engagement of medication for opioid use disorder for 30 days after initiation (7.4% vs. 5.3%; OR 6.9, 95% CI -0.01 to 13.81).
Conclusion
In hospitalized adults with an admission or discharge diagnosis of opioid use disorder, addiction consultation service was superior to usual care with respect to the rate of initiation of medication for opioid use disorder in the first 14 days after hospital discharge.
Reference
Jennifer McNeely, Scarlett S Wang, Yasna Rostam Abadi et al. Addiction Consultation Services for Opioid Use Disorder Treatment Initiation and Engagement: A Randomized Clinical Trial. JAMA Intern Med. 2024 Sep 1;184(9):1106-1115.
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