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Triamcinolone hexacetonide

Class
Steroid hormones
Subclass
Glucocorticoids
Generic name
Triamcinolone hexacetonide
Brand names
Hexatrione®
Common formulations
Suspension for injection
See also
Triamcinolone acetonide (Kenalog®, Triderm®, Nasacort®, Xipere®, Triesence®)
Triamcinolone acetonide ER (Zilretta®)
Indications for use
Labeled indications
Adults
•
Treatment of alopecia areata
•
Treatment of discoid lupus erythematosus
•
Treatment of granuloma annulare (localized lesions)
•
Treatment of keloids
•
Treatment of lichen planus (localized lesions)
•
Treatment of LSC (treatment of localized lesions)
•
Treatment of necrobiosis lipoidica in patients with necrobiosis lipoidica diabeticorum
•
Treatment of plaque psoriasis (localized lesions)
Safety risks
Contraindications
Hypersensitivity to benzyl alcohol
Hypersensitivity to triamcinolone hexacetonide or any component of the product
Epidural or intrathecal administration
Warnings and precautions
Bone fracture, decreased bone mineral density
•
Use caution in patients with or at increased risk of osteoporosis.
Exacerbation of increased intraocular pressure
•
Use caution in patients with elevated intraocular pressure.
Exacerbation of peripheral edema, CVD, weight gain, increased BP
•
Use caution in patients with congestive HF or hypertension. Consider dietary salt restriction and potassium supplementation.
Hypothalamic-pituitary-adrenal axis suppression, immunosuppression
•
Use caution in all patients on corticosteroids.
Mood changes
•
Use caution in patients with previous or current emotional instability or psychiatric illness.
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
•
No guidance available.
Renal replacement therapy
Any modality
•
No guidance available.
Hepatic impairment
Any severity
•
No guidance available.
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B3
•
Use only if benefits outweigh potential risks. Evidence of fetal harm in humans. Infatns should be monitored for adrenal insufficiency. Corticosteroids have been shown to be teratogenic in many species when given in doses equivalent to the human dose. There are no adequate and well controlled studies in pregnant women. Corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Breastfeeding
Consider alternative agents that may be safer.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Some adverse effects on lactation reported.
Adverse reactions
Unknown frequency
•
Anaphylaxis, angioedema, osteoporosis, burning sensation, injection site pain, injection site reactions, skin rash, skin erythema, urticaria
Interactions
Drug(s)
Check Interactions
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