Trazodone
Class
Antidepressants
Subclass
5-HT receptor mixed agonist-antagonist
Substance name
traZODone hydrochloride
Common formulations
Tablet
Dosage and administration
Adults patients
Major depressive disorder
Insomnia in patients with Alzheimer's disease • Off-label
Insomnia in patients with PTSD • Off-label
Nightmares in patients with PTSD • Off-label
Other off-label uses
Indications for use
Labeled indications
Adults
Off-label indications
Adults
Safety risks
Boxed warnings
Suicidal ideation
Contraindications
Hypersensitivity to trazodone or its components
Myocardial infarction in the acute recovery phase
QT prolongation
Concomitant use of MAOIs
Concomitant use of QT-prolonging agents
Warnings and precautions
Acute angle-closure glaucoma
Antidepressant discontinuation syndrome
Bleeding
Cardiac arrhythmias
Manic or mixed episodes
Orthostatic hypotension, syncope, decreased serum sodium
Priapism
Serotonin syndrome
Somnolence, cognitive difficulties, motor impairment
Specific populations
Renal impairment
CrCl 0-90 mL/min
Renal replacement therapy
Continuous renal replacement
Intermittent hemodialysis
Peritoneal dialysis
Hepatic impairment
Any severity
Pregnancy and breastfeeding
Pregnancy
All trimesters
Breastfeeding
Use only if benefits outweigh potential risks.
Unknown drug levels in breastfed infants.
No overt adverse effects reported in breastfed infants.
No overt adverse effects on lactation reported.
Adverse reactions
Very common > 10%
Common 1-10%
Uncommon < 1%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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