Sulopenem / probenecid
Class
Antibiotics
Subclass
Thiopenem / renal tubular transport inhibitor combination
Substance name
Sulopenem / probenecid
Brand names
Orlynvah®
Contains
Probenecid
Sulopenem
Common formulations
Tablet
Dosage and administration
Adults patients
Treatment of UTIs in females • Uncomplicated cystitis, caused by E. coli, K. pneumoniae, or P. mirabilis, if limited or no alternative oral antibiotic options are available
Indications for use
Labeled indications
Adults
Safety risks
Contraindications
Hypersensitivity to sulopenem/probenecid or its components or to other β-lactams
Blood dyscrasias
Uric acid nephrolithiasis
Concomitant use of ketorolac tromethamine or ketoprofen
Warnings and precautions
Antimicrobial resistance
C. difficile infection
Exacerbation of gout
Increased serum sulopenem levels
Increased urine glucose
Uric acid nephrolithiasis
Specific populations
Renal impairment
CrCl ≥ 15 mL/min
CrCl < 15 mL/min
Renal replacement therapy
Any modality
Hepatic impairment
Any severity
Pregnancy and breastfeeding
Pregnancy
All trimesters
Breastfeeding
Use only if benefits outweigh potential risks.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Common 1-10%
Uncommon < 1%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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