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Ranitidine

Oral
Intravenous
Intramuscular
Class
Acid suppression agents
Subclass
H2-antihistamines
Substance name
raNITIdine hydrochloride
Common formulations
Tablet
Dosage and administration
Adults patients
No dosages available
Other off-label uses
•
Treatment of laryngopharyngeal reflux
Indications for use
Labeled indications
Adults
•
Symptomatic relief of GERD
•
Treatment of duodenal ulcer
•
Treatment of duodenal ulcer (active)
•
Treatment of gastric ulcer
•
Treatment of gastric ulcer (active, benign)
•
Treatment of pathological hypersecretory gastrointestinal conditions
Children
•
Treatment of GERD
Off-label indications
Adults
•
Treatment of laryngopharyngeal reflux
Safety risks
Contraindications
A known hypersensitivity to Ranitidine
Pre-existing acute porphyria
Warnings and precautions
Exacerbation of peptic ulcer disease
•
Use caution with Tobacco smoking.
Vitamin B12 deficiency
•
Use caution with daily treatment of gastric acid-suppressing medication such as nizatidine over a long period of time (e.g., generally > 3 years).
Specific populations
Renal impairment
eGFR 20-50 mL/min/1.73 m²
•
Use acceptable. No dose adjustment required.
eGFR 10-20 mL/min/1.73 m²
•
Use acceptable. No dose adjustment required.
eGFR < 10 mL/min/1.73 m²
•
Reduce dose by 0-50%.
Renal replacement therapy
Continuous renal replacement
•
Use acceptable. No dose adjustment required.
Intermittent hemodialysis
•
Dose as in eGFR < 10 mL/min/1.73 m². Reduce dose by 50%.
Peritoneal dialysis
•
Dose as in eGFR < 10 mL/min/1.73 m². Reduce dose by 50%.
Hepatic impairment
Any severity
•
Use with caution.
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B1
•
Use only if benefits outweigh potential risks.
Breastfeeding
Do not use during breastfeeding.
•
Consider alternative agents that may be safer.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Unlikely to cause adverse effects in breastfed infants.
Some adverse effects on lactation reported.
Adverse reactions
Common 1-10%
•
Infections, abdominal pain, asthenia, cough, diarrhea, headache, nausea, vomiting
Rare < 0.1%
•
Acute liver failure, agranulocytosis, aplastic anemia, pancytopenia
Unknown frequency
•
Acute pancreatitis, agitation, alopecia, anaphylaxis, angioedema, asystole, bradycardia, bronchospasm, cardiac arrest, cholestatic jaundice, cholestatic liver disease, chorea, contact dermatitis, ↓ WBC count, ↓ blood neutrophil count, ↓ platelet count, delirium, drug-induced liver injury, dystonia, erythema multiforme, gastric cancer, gout, gynecomastia, hemolytic anemia, hepatitis, hypergastrinemia, hypotension, ↑ LFTs, ↑ intraocular pressure, ↑ serum creatinine, ↑ serum prolactin, meningitis, photosensitivity of skin, pneumonia, angina pectoris, arthralgia, blurred vision, confusion, constipation, ↓ libido, depression, erectile dysfunction, fever, fever, hallucinations, mania, myalgia, paranoid ideation, skin rash, skin rash, vertigo, Stevens-Johnson syndrome, toxic epidermal necrolysis, tubulointerstitial nephritis, vasculitis, vitamin B12 deficiency
Interactions
Drug(s)
Check Interactions
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