Prucalopride

Class
Laxatives
Subclass
5-HT4 receptor agonists
Substance name
Prucalopride
Brand names
Motegrity®
Common formulations
Film-coated tablet
Dosage and administration
Adults patients
Treatment of constipation • Chronic
•
2 mg PO daily
Indications for use
Labeled indications
Adults
•
Treatment of constipation (chronic)
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B1
•
Avoid use.
Breastfeeding
Little information available on breastfeeding safety.
•
Acceptable for use during breastfeeding. Use with caution during breastfeeding.
Low excretion in breastmilk (5-25%).
Unknown drug levels in breastfed infants.
Adverse reactions
Very common > 10%
•
Abdominal pain, diarrhea, headache, nausea
Common 1-10%
•
Abdominal swelling, ↓ bowel sounds, migraine, dizziness, fatigue, flatulence, loss of appetite, urinary frequency, vomiting
Unknown frequency
•
Facial edema, dyspnea, generalized pruritus, skin rash, suicidal ideation, visual hallucinations, urticaria
Interactions
Drug(s)
Check Interactions
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