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Plecanatide

Class
Laxatives
Subclass
Guanylate cyclase 2C receptor agonists
Generic name
Plecanatide
Brand names
Trulance®
Common formulations
Tablet
Indications for use
Labeled indications
Adults
•
Treatment of constipation (chronic)
•
Treatment of IBS in females (severe, diarrhea-predominant)
Pregnancy and breastfeeding
Pregnancy
All trimesters
•
Insufficient evidence. Maternal use is not expected to result in fetal exposure to the drug due to negligible systemic drug absorption following oral administration.
Breastfeeding
Unlikely to have adverse effects in breastfed infants.
•
Acceptable for use during breastfeeding.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Common 1-10%
•
Abdominal swelling, abdominal tenderness, nasopharyngitis, diarrhea, dizziness, flatulence, nausea, sinusitis, urinary tract infections, upper respiratory tract infections
Uncommon < 1%
•
↑ serum ALT, ↑ serum AST
Unknown frequency
•
Hives, itching, skin rash
Interactions
Drug(s)
Check Interactions
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