Patisiran
Class
Anti-amyloid agents
Subclass
RNA interference therapeutics
Generic name
Patisiran
Brand names
Onpattro®
Common formulations
Solution for injection
Safety risks
Contraindications
A known hypersensitivity to patisiran or any of its components
Warnings and precautions
Coagulopathy
Thrombocytopenia
Specific populations
Renal impairment
eGFR ≥ 30 mL/min/1.73 m²
eGFR < 30 mL/min/1.73 m²
Renal replacement therapy
Continuous renal replacement
Intermittent hemodialysis
Peritoneal dialysis
Hepatic impairment
Child-Pugh A (mild)
Child-Pugh B (moderate)
Child-Pugh C (severe)
Pregnancy and breastfeeding
Pregnancy
All trimesters
Breastfeeding
Little information available on breastfeeding safety.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Very common > 10%
Common 1-10%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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