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Paricalcitol

Oral
Intravenous
Class
Anti-parathyroid hormone agents
Subclass
Vitamin D analogs
Generic name
Paricalcitol
Brand names
Zemplar®
Common formulations
Capsule
Safety risks
Boxed warnings
Seizures
•
Use extreme caution with a history of seizure disorder and with acute hypercalcemia.
Contraindications
Acute hypercalcemia
Known hypersensitivity to paricalcitol or any of the inactive ingredients
Warnings and precautions
Hypercalcemia
•
Use caution with a history of hypercalcemia or concomitant administration of high doses of calcium-containing preparations, thiazide diuretics, or other vitamin D compounds.
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
•
Use acceptable. No dose adjustment required.
Renal replacement therapy
Continuous renal replacement
•
Use acceptable. No dose adjustment required.
Intermittent hemodialysis
•
Use acceptable. No dose adjustment required.
Peritoneal dialysis
•
Use acceptable. No dose adjustment required.
Hepatic impairment
Child-Pugh A (mild)
•
Use acceptable. No dose adjustment required.
Child-Pugh B (moderate)
•
Use acceptable. No dose adjustment required.
Child-Pugh C (severe)
•
No guidance available.
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: C
•
Use only if benefits outweigh potential risks. Evidence of fetal harm in animals. If a pregnant woman is taking paricalcitol, she should not take additional vitamin D or its derivatives.
Breastfeeding
Little information available on breastfeeding safety.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Very common > 10%
•
↑ serum calcium, diarrhea, nausea, rhinitis
Common 1-10%
•
Angioedema, arthritis, asthma, chronic kidney disease, conjunctivitis, edema, gastrointestinal bleeding, hypertension, hypervolemia, hypotension, influenza virus infection, nasopharyngitis, peritonitis, pneumonia, arthralgia, constipation, dizziness, dry mouth, fever, headache, insomnia, malaise, palpitations, skin rash, syncope, urinary urgency, vertigo, vomiting, sepsis, shivering, urticaria
Interactions
Drug(s)
Check Interactions
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