Ctrl

K

Oxymetholone

Class
Steroid hormones
Subclass
Androgens
Generic name
Oxymetholone
Brand names
Anadrol-50®
Common formulations
Tablet
Dosage and administration
Adults patients
Treatment of anemia • Caused by deficient red cell production
•
1-5 mg/kg PO daily
Indications for use
Labeled indications
Adults
•
Treatment of anemia (caused by deficient red cell production)
Safety risks
Contraindications
Breast cancer or prostate cancer
Hepatic dysfunction
Pre-existing cardiac, renal, or hepatic disease
Warnings and precautions
Atherosclerosis
•
Use caution with decreased high density lipoprotein and increased low density lipoprotein.
Coagulopathy
•
Use caution with a history of bleeding complications.
Exacerbation of glycemic control
•
Use caution with diabetes mellitus.
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
•
Use acceptable. No dose adjustment required.
Renal replacement therapy
Any modality
•
Use acceptable. No dose adjustment required.
Hepatic impairment
Child-Pugh C (severe)
•
Do not use.
Any severity
•
No guidance available.
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: D
•
Avoid use. Evidence of fetal harm in humans. Oxymetholone is classified as FDA pregnancy category X.
•
Fetal harm can occur and use is contraindicated in pregnant women or in women who may become pregnant while on therapy.
•
Women who become pregnant during therapy should be appraised of the potential risk to the fetus.
•
Additionally, impairment of fertility is possible with oxymetholone therapy; oligospermia may occur in males and amenorrhea may occur in females.
Breastfeeding
Little information available on breastfeeding safety.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Unknown frequency
•
Acne, alopecia, bladder injury, cholestatic jaundice, clitoromegaly, coagulopathy, ↓ serum HDL, edema, electrolyte imbalance, epididymitis, erectile dysfunction, gynecomastia, hepatitis, hirsutism, impaired glucose tolerance, iron deficiency anemia, liver cancer, low density lipoprotein levels raised (serum or plasma), premature epiphyseal closure, change in voice, ↓ libido, diarrhea, ↑ libido, insomnia, menstrual irregularity, muscle cramps, nausea, priapism, vomiting, shivering, testicular atrophy, virilization
Interactions
Drug(s)
Check Interactions
Reset

What did you think about this content?

Create free account

Sign up for free to access the full drug resource