Nifedipine
Class
Antihypertensives
Subclass
Dihydropyridine calcium channel blockers
Substance name
NIFEdipine
Common formulations
Capsule
See also
Nifedipine ER (Procardia XL®, Adalat CC®)
Dosage and administration
Adults patients
Symptomatic relief
Achalasia • Off-label
Treatment
Stable angina
Vasospastic angina
Hypertension in pregnancy • Acute, severe • Off-label
Pulmonary arterial hypertension • Off-label
Raynaud's phenomenon • Off-label
Tenesmus in patients with cancer • Off-label
Other off-label uses
Indications for use
Labeled indications
Adults
Off-label indications
Adults
Safety risks
Contraindications
Hypersensitivity to nifedipine or its components
Cardiogenic shock
Concomitant use of high-dose fentanyl
Concomitant use of potent CYP3A inducers
Warnings and precautions
HF
Increased serum nifedipine levels
Peripheral edema, severe hypotension, angina pectoris, myocardial infarction
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
Renal replacement therapy
Continuous renal replacement
Intermittent hemodialysis
Peritoneal dialysis
Hepatic impairment
Any severity
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: C
Breastfeeding
Use only if benefits outweigh potential risks.
Unknown drug levels in breastfed infants.
No overt adverse effects reported in breastfed infants.
No overt adverse effects on lactation reported.
Adverse reactions
Very common > 10%
Common 1-10%
Uncommon < 1%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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