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Miltefosine

Class
Antiprotozoal agents
Subclass
Alkylphosphocholines
Substance name
Miltefosine
Brand names
Impavido®
Common formulations
Capsule
Dosage and administration
Adults patients
Treatment of leishmaniasis • Visceral, cutaneous, mucosal
Weight 45 kg or greater
•
50 mg PO TID for 28 days
Indications for use
Labeled indications
Adults
•
Treatment of leishmaniasis (visceral, cutaneous, mucosal)
Children
•
Treatment of leishmaniasis (visceral, cutaneous, mucosal)
Adverse reactions
Very common > 10%
•
↓ platelet count, ↑ liver enzymes, ↑ serum creatinine, motion sickness, abdominal pain, diarrhea, dizziness, headache, loss of appetite, nausea, testicular pain, vomiting
Common 1-10%
•
Anemia, cellulitis, asthenia, constipation, fever, generalized pruritus, malaise, skin rash, somnolence, skin abscess, Stevens-Johnson syndrome, testicular swelling
Unknown frequency
•
Acute pancreatitis, agranulocytosis, arthritis, ↓ sperm concentration, ↑ WBC count, ↑ serum TBIL, jaundice, oligozoospermia, melena, seizure
Interactions
Drug(s)
Check Interactions
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