Methylene blue
Class
Oxidizing agents
Subclass
NADPH-MetHb reductase stimulants
Generic name
Methylene blue, methylthioninium chloride
Brand names
Provayblue®
Common formulations
Solution for injection
Dosage and administration
Adults patients
Treatment of methemoglobinemia • Drug-induced
Other off-label uses
Indications for use
Labeled indications
Adults
Off-label indications
Adults
Safety risks
Contraindications
G6PD deficiency
Severe hypersensitivity reactions to methylene blue or any other thiazine dye
The concomitant use of methylene blue with SSRIs, SNRIs, and MAOIs
Warnings and precautions
Hemolysis
Specific populations
Renal impairment
eGFR ≥ 60 mL/min/1.73 m²
eGFR 15-59 mL/min/1.73 m²
Renal replacement therapy
Continuous renal replacement
Intermittent hemodialysis
Peritoneal dialysis
Hepatic impairment
Any severity
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: D
Breastfeeding
Little information available on breastfeeding safety.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Unlikely to cause adverse effects in breastfed infants.
Adverse reactions
Common 1-10%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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