Meclofenamate

Class
Nonsteroidal anti-inflammatory drugs
Subclass
Fenamates
Substance name
Meclofenamate
Common formulations
Capsule
Dosage and administration
Adults patients
Axial spondyloarthritis
•
50-100 mg PO q6-8h
Osteoarthritis
•
50-100 mg PO q6-8h for 2-3 weeks, if no improvement may be required to obtain the optimum therapeutic benefit
Primary dysmenorrhea
•
100 mg PO TID for 6 days
Rheumatoid arthritis
•
50-100 mg PO q6-8h for 2-3 weeks
Indications for use
Labeled indications
Adults
•
Symptomatic relief of axial spondyloarthritis
•
Symptomatic relief of fever
•
Symptomatic relief of osteoarthritis
•
Symptomatic relief of pain
•
Symptomatic relief of primary dysmenorrhea
•
Symptomatic relief of rheumatoid arthritis
•
Symptomatic relief of shoulder pain
•
Treatment of osteoarthritis
•
Treatment of primary dysmenorrhea
•
Treatment of rheumatoid arthritis (moderate-to-severe, active)
Children
•
Symptomatic relief of juvenile arthritis
Pregnancy and breastfeeding
Breastfeeding
Consider alternative agents that may be safer.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Very common > 10%
•
Diarrhea, nausea
Common 1-10%
•
Edema, peptic ulcer disease, abdominal pain, constipation, dizziness, flatulence, generalized pruritus, headache, heartburn, loss of appetite, skin rash, tinnitus, stomatitis, urticaria
Uncommon < 1%
•
Agranulocytosis, ↓ WBC count, ↓ blood neutrophil count, erythema multiforme, erythroderma, hemolytic anemia, renal failure, Stevens-Johnson syndrome, thrombotic thrombocytopenic purpura
Unknown frequency
•
AKI, acute liver failure, anaphylactoid reactions, anemia, cerebrovascular accident, coagulation disorder, congestive heart failure, DRESS syndrome, fulminant hepatic failure, gastrointestinal hemorrhage, gastrointestinal perforation, hepatic necrosis, hypertension, ↑ liver enzymes, jaundice, myocardial infarction, ↑PT, renal papillary necrosis, steatorrhea, thrombosis, toxic epidermal necrolysis
Interactions
Drug(s)
Check Interactions
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