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Lincomycin

Intravenous
Intramuscular
Subconjunctival
Class
Antibiotics
Subclass
Lincosamides
Substance name
Lincomycin hydrochloride
Brand names
Lincocin®
Common formulations
Solution for injection
Dosage and administration
Adults patients
Treatment of Staphylococcus infection
•
Maintenance: 0.6-1 g IV q8-12h
•
Maximum: 8 g per day
Indications for use
Labeled indications
Adults
•
Treatment of Staphylococcus infection
•
Treatment of pneumococcal infections
•
Treatment of streptococcal infection
Safety risks
Contraindications
Hypersensitive to lincomycin or clindamycin or any of the drug's components
Warnings and precautions
C. difficile infection
•
Use extreme caution in all patients including patients who present with diarrhea following antibiotic use.
Decreased CSF lincomycin levels
•
Maintain a high level of suspicion in patients with meningitis as, concentrations of lincomycin in the CSF may be inadequate for the treatment of meningitis.
Gasping syndrome
•
Maintain a high level of suspicion, as the preservative benzyl alcohol has been associated with serious adverse events.
Specific populations
Renal impairment
GFR 50-80 mL/min
•
Use acceptable. No dose adjustment required. Monitor serum concentrations.
GFR 30-50 mL/min
•
Use with caution. Monitor serum concentrations.
GFR < 30 mL/min
•
Reduce dose by 70-75%. Monitor serum concentrations.
Renal replacement therapy
Any modality
•
Reduce dose by 70-75%. Monitor serum concentrations.
Hepatic impairment
Any severity
•
Use with caution.
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: A
•
Use only if clearly needed. Evidence of fetal harm in humans. Parenteral lincomycin contains benzyl alcohol, which can cross the placenta and has been associated with neonatal gasping syndrome.
Breastfeeding
Little information available on breastfeeding safety.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Unknown frequency
•
AKI, acute generalized exanthematous pustulosis, agranulocytosis, anaphylaxis, angioedema, aplastic anemia, C. difficile colitis, cardiac arrest, cardiac arrhythmias, ↓ WBC count, ↓ blood neutrophil count, erythema multiforme, erythroderma, glossitis, hypotension, ↑ BUN, ↑ LFTs, ↑ urine protein, jaundice, myasthenia gravis, pancytopenia, premature atrial contractions, premature ventricular contractions, pseudomembranous colitis, abdominal discomfort, abdominal pain, anal itching, diarrhea, dizziness, generalized pruritus, headache, injection site pain, injection site reactions, low urine output, nausea, skin rash, somnolence, tinnitus, vertigo, vomiting, respiratory arrest, ST-segment depression, serum sickness, Stevens-Johnson syndrome, stomatitis, thrombotic thrombocytopenic purpura, thrombophlebitis, toxic epidermal necrolysis, tubulointerstitial nephritis, urticaria, vaginitis, vesiculobullous rash
Interactions
Drug(s)
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