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Lifitegrast

Class
Integrin antagonists
Subclass
LFA-1 / ICAM-1 antagonists
Substance name
Lifitegrast
Brand names
Xiidra®
Common formulations
Ophthalmic solution
Dosage and administration
Adults patients
Treatment of dry eye disease
•
1 gtt OPHTH BID (5%)
Indications for use
Labeled indications
Adults
•
Treatment of dry eye disease
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B1
•
Use only if benefits outweigh potential risks. Evidence of fetal harm in animals.
Breastfeeding
Acceptable for use during breastfeeding.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Very common > 10%
•
Application site reactions, ↓ visual acuity, change in taste
Common 1-10%
•
Conjunctival injection, blurred vision, eye discharge, eye irritation, headache, itchy eyes, tearing, visual disturbances, sinusitis
Unknown frequency
•
Acute respiratory distress syndrome, allergic conjunctivitis, anaphylaxis, angioedema, atopic dermatitis, bronchospasm, eyelid swelling, dyspnea, skin rash, tongue swelling, urticaria
Interactions
Drug(s)
Check Interactions
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