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Indocyanine green

Class
Radiographic contrast agents
Subclass
Fluorescent dyes
Generic name
Indocyanine green
Common formulations
Kit for injection after reconstitution
Dosage and administration
Adults patients
Preparation for determination of cardiac output
•
5 mg IV once
Indications for use
Labeled indications
Adults
•
Preparation for determination of cardiac output
Children
•
Preparation for determination of cardiac output
Safety risks
Contraindications
Iodine hypersensitivity
•
Prior to using Indocyanine Green, assess patients for a history of hypersensitivity reactions and consider alternative diagnostic methods if such allergies are identified.
Warnings and precautions
Allergic reactions
•
Use caution with a history of allergic reactions to dyes. Prior to using Indocyanine Green, assess patients for a history of allergic reactions to dyes and consider alternative diagnostic methods if such allergies are identified. Initiate appropriate treatment based on the severity of the reaction, which may include administering antihistamines, corticosteroids, and supportive care.
Exacerbation of renal failure
•
Use caution with pre-existing renal failure or uremia, and those who are on dialysis. Assess patients for pre-existing renal conditions and monitor closely. Provide supportive care and consider appropriate medical interventions such as hemodialysis if necessary.
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
•
Use acceptable. No dose adjustment required.
Renal replacement therapy
Continuous renal replacement
•
Use acceptable. No dose adjustment required.
Intermittent hemodialysis
•
Use acceptable. No dose adjustment required.
Peritoneal dialysis
•
Use acceptable. No dose adjustment required.
Hepatic impairment
Any severity
•
Use acceptable. No dose adjustment required.
Pregnancy and breastfeeding
Pregnancy
All trimesters
•
Use only if clearly needed. Animal reproduction studies have not been conducted.
•
There are no controlled data in human pregnancy.
Breastfeeding
Use with caution during breastfeeding.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Common 1-10%
•
Hypotension, nausea, vomiting
Uncommon < 1%
•
Anaphylaxis, itching, urticaria
Unknown frequency
•
Agitation, bronchospasm, cardiac arrest, cyanosis, diaphoresis, laryngospasm, peripheral vasodilation, pharyngitis, anxiety, confusion, cough, dyspnea, headache, palpitations, skin flushing, syncope, visual disturbances, weakness, respiratory depression, sinus tachycardia, skin discoloration, skin erythema, wheezing
Interactions
Drug(s)
Check Interactions
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