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Icosapent ethyl

Class
Hypolipidemic agents
Subclass
Omega-3 fatty acids
Substance name
Ethyl eicosapentaenoic acid (E-EPA)
Brand names
Vascepa®
Common formulations
Capsule
Dosage and administration
Adults patients
Treatment
Hypertriglyceridemia • Severe
•
2 g PO BID
Taken with food.
Adjunctive treatment
Adjunctive treatment for hypertriglyceridemia • Mild-to-moderate, with established CVD or diabetes mellitus and ≥ 2 additional risk factors for CVD
•
2 g PO BID
Taken with food.
Indications for use
Labeled indications
Adults
•
Treatment of hypertriglyceridemia (severe)
•
Adjunctive treatment for hypertriglyceridemia (mild-to-moderate, with established CVD or diabetes mellitus and ≥ 2 additional risk factors for CVD)
Safety risks
Contraindications
Hypersensitivity to icosapent ethyl or its components
Warnings and precautions
AF, atrial flutter
•
Maintain a high level of suspicion, as icosapent ethyl has been associated with an increased risk of AF and atrial flutter requiring hospitalization.
Allergic reactions
•
Use caution in patients with fish allergy, as icosapent ethyl contains ethyl esters of the omega-3 fatty acid, eicosapentaenoic acid, obtained from fish oil.
Bleeding
•
Maintain a high level of suspicion, as icosapent ethyl has been associated with an increased risk of bleeding, especially in patients receiving concomitant antithrombotic agents, such as aspirin, clopidogrel, or warfarin.
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
•
No guidance available.
Renal replacement therapy
Any modality
•
No guidance available.
Hepatic impairment
Any severity
•
No guidance available. Monitor serum aminotransferases.
Pregnancy and breastfeeding
Pregnancy
All trimesters
•
Use only if benefits outweigh potential risks. Evidence of fetal harm in animals.
Breastfeeding
Use only if benefits outweigh potential risks.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Common 1-10%
•
Gout, atrial fibrillation, arthralgia, throat pain, musculoskeletal pain, peripheral edema, constipation
Unknown frequency
•
Atrial flutter, diarrhea, ↑ serum triglycerides, pain in extremity, abdominal discomfort, bleeding
Interactions
Drug(s)
Check Interactions
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