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Icosapent ethyl

Class
Hypolipidemic agents
Subclass
Omega-3 fatty acids
Substance name
Ethyl eicosapentaenoic acid (E-EPA)
Brand names
Vascepa®
Common formulations
Capsule
Dosage and administration
Adults patients
Treatment
HypertriglyceridemiaSevere
2 g PO BID
Taken with food.
Adjunctive treatment
Adjunctive treatment for hypertriglyceridemiaMild-to-moderate, with established CVD or diabetes mellitus and ≥ 2 additional risk factors for CVD
2 g PO BID
Taken with food.
Indications for use
Labeled indications
Adults
Treatment of hypertriglyceridemia (severe)
Adjunctive treatment for hypertriglyceridemia (mild-to-moderate, with established CVD or diabetes mellitus and ≥ 2 additional risk factors for CVD)
Safety risks
Contraindications
Hypersensitivity to icosapent ethyl or its components
Warnings and precautions
AF, atrial flutter
Maintain a high level of suspicion, as icosapent ethyl has been associated with an increased risk of AF and atrial flutter requiring hospitalization.
Allergic reactions
Use caution in patients with fish allergy, as icosapent ethyl contains ethyl esters of the omega-3 fatty acid, eicosapentaenoic acid, obtained from fish oil.
Bleeding
Maintain a high level of suspicion, as icosapent ethyl has been associated with an increased risk of bleeding, especially in patients receiving concomitant antithrombotic agents, such as aspirin, clopidogrel, or warfarin.
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
No guidance available.
Renal replacement therapy
Any modality
No guidance available.
Hepatic impairment
Any severity
No guidance available. Monitor serum aminotransferases.
Pregnancy and breastfeeding
Pregnancy
All trimesters
Use only if benefits outweigh potential risks. Evidence of fetal harm in animals.
Breastfeeding
Use only if benefits outweigh potential risks.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Common 1-10%
Gout, atrial fibrillation, arthralgia, throat pain, musculoskeletal pain, peripheral edema, constipation
Unknown frequency
Atrial flutter, diarrhea, ↑ serum triglycerides, pain in extremity, abdominal discomfort, bleeding
Interactions
Drug(s)
Check Interactions
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