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Hyoscyamine ER

Class
Anticholinergics
Subclass
Muscarinic receptor antagonists
Generic name
Hyoscyamine sulfate ER
Brand names
Hyoscyamine ER®
Common formulations
Tablet
Safety risks
Boxed warnings
Exacerbation of autonomic neuropathy
•
Use extreme caution with pre-existing autonomic neuropathy.
Exacerbation of gastrointestinal infections
•
Use extreme caution with suspected or known infectious diarrhea.
Contraindications
Myasthenia gravis
Bladder obstruction or other urinary tract obstruction
Gastrointestinal obstruction, pyloroduodenal obstruction, paralytic ileus, intestinal atony, severe ulcerative colitis, or toxic megacolon
Glaucoma
Warnings and precautions
Gastrointestinal motility disorders
•
Use caution with GERD.
Psychosis
•
Use caution with a history of confusion, disorientation, short-term memory loss, hallucinations, dysarthria, ataxia, coma, euphoria, anxiety, fatigue, insomnia, agitation, and mannerisms.
Respiratory conditions
•
Use caution with chronic pulmonary disease.
Urinary retention
•
Use caution with a history of prostatic hypertrophy or renal impairment.
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
•
Use acceptable. No dose adjustment required.
Renal replacement therapy
Any modality
•
Use acceptable. No dose adjustment required.
Hepatic impairment
Any severity
•
Use acceptable. No dose adjustment required.
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B2
•
Use only if benefits outweigh potential risks. Evidence of fetal harm in humans.
Breastfeeding
Little information available on breastfeeding safety.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Common 1-10%
•
Blurred vision, confusion, constipation, dry mouth, palpitations, somnolence, urinary retention, sinus tachycardia
Uncommon < 1%
•
Abdominal distension, hypertension, hallucinations, loss of sweating, nausea, skin flushing, vomiting, respiratory depression
Unknown frequency
•
Cycloplegia, dysgeusia, erectile dysfunction, ileus, mydriasis, psychosis, dizziness, dyspepsia, dysphagia, headache, insomnia, photophobia, weakness, urticaria
Interactions
Drug(s)
Check Interactions
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