Hyoscyamine ER
Class
Anticholinergics
Subclass
Muscarinic receptor antagonists
Generic name
Hyoscyamine sulfate ER
Brand names
Hyoscyamine ER®
Common formulations
Tablet
Safety risks
Boxed warnings
Exacerbation of autonomic neuropathy
Exacerbation of gastrointestinal infections
Contraindications
Myasthenia gravis
Bladder obstruction or other urinary tract obstruction
Gastrointestinal obstruction, pyloroduodenal obstruction, paralytic ileus, intestinal atony, severe ulcerative colitis, or toxic megacolon
Glaucoma
Warnings and precautions
Gastrointestinal motility disorders
Psychosis
Respiratory conditions
Urinary retention
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
Renal replacement therapy
Any modality
Hepatic impairment
Any severity
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B2
Breastfeeding
Little information available on breastfeeding safety.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Common 1-10%
Uncommon < 1%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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