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Ferumoxytol

Class
Iron replacement
Subclass
Iron complexes
Substance name
Ferumoxytol
Brand names
Feraheme®
Common formulations
Solution for injection
Indications for use
Labeled indications
Adults
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Treatment of iron deficiency anemia in patients with CKD (unsatisfactory response to oral iron, intolerant to oral iron)
Pregnancy and breastfeeding
Pregnancy
All trimesters
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Use only if benefits outweigh potential risks. Evidence of fetal harm in humans. Fetal adverse reactions, including fetal bradycardia, have been associated with maternal hypersensitivity reactions to parenteral iron products, especially during the second and third trimesters of pregnancy.
•
Data on ferumoxytol use in human pregnancy are insufficient to inform a drug-associated risk of adverse developmental outcomes.
•
Untreated iron deficiency anemia is associated with a risk to the mother and fetus including postpartum anemia, preterm delivery, and low birth weight. In animal studies, maternal doses equivalent to 2 times the recommended human dose during organogenesis did not result in adverse maternal or fetal effects.
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However, maternally toxic doses of 6 times the recommended human dose administered during organogenesis did result in decreased fetal weights and fetal malformations.
Breastfeeding
Consider alternative agents that may be safer.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Common 1-10%
•
Edema, hypertension, hypotension, peripheral edema, abdominal pain, back pain, chest pain, constipation, cough, diarrhea, dizziness, dyspnea, fever, generalized pruritus, headache, injection site reactions, muscle spasms, nausea, skin rash, vomiting
Uncommon < 1%
•
Allergic reactions
Unknown frequency
•
Anaphylaxis, anemia, angioedema, cardiac arrest, congestive heart failure, cyanosis, gastroenteritis, ischemic cardiomyopathy, myocardial infarction, pneumonia, pulse deficit, renal failure, loss of consciousness, seizure, syncope, silent myocardial ischemia, tachycardia
Interactions
Drug(s)
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