Etelcalcetide

Use extreme caution with pre-existing HF along with hypocalcemia. Evaluate patients' cardiovascular status before initiating Etelcalcetide, especially in those with a history of HF or cardiac dysfunction. Consider discontinuing or adjusting Etelcalcetide, provide appropriate HF management, and closely monitor the patient's cardiovascular status, under medical supervision.

Administer Etelcalcetide under medical supervision with appropriate monitoring for signs of anaphylactic reactions.

Monitor serum calcium levels before and during Etelcalcetide treatment, and manage hypocalcemia risk factors appropriately.

Use caution with a history of gastritis, esophagitis, peptic ulcer disease, or severe vomiting. Assess patients for risk factors of gastrointestinal bleeding, including a history of bleeding disorders or concurrent use of anticoagulants, and monitor them closely during treatment. Discontinue Etelcalcetide, initiate appropriate medical treatment for bleeding.

Use caution with a history of seizure disorder or if they develop hypocalcemia during treatment with etelcalcetide. Use Etelcalcetide cautiously in patients with a history of seizures or predisposing factors, and consider alternative treatments if appropriate. Assess their severity, consider adjusting the Etelcalcetide dose, and provide appropriate medical intervention for seizure management, under medical supervision.

Use caution with congenital long QT syndrome, history of QT prolongation, family history of long QT syndrome or SCD. Monitor cardiac function and electrolyte levels during Etelcalcetide treatment, especially in patients at risk for ventricular arrhythmias. Consider discontinuing or adjusting Etelcalcetide, provide appropriate medical management for arrhythmias, and closely monitor the patient's cardiac status.