Eplerenone
Class
Diuretics
Subclass
Mineralocorticoid receptor antagonists
Substance name
Eplerenone
Brand names
Inspra®
Common formulations
Film-coated tablet
Dosage and administration
Adults patients
HFrEF • After myocardial infarction
Hypertension
HFrEF • Off-label
Primary aldosteronism • Off-label
Other off-label uses
Indications for use
Labeled indications
Adults
Off-label indications
Adults
Safety risks
Contraindications
Hypersensitivity to eplerenone or its components
Hypertension in patients with diabetes mellitus type 2 with microalbuminuria or elevated serum creatinine
Warnings and precautions
Increased serum potassium
Specific populations
Renal impairment
eGFR ≥ 50 mL/min/1.73 m²
eGFR 30-49 mL/min/1.73 m²
eGFR ≤ 30 mL/min/1.73 m²
Renal replacement therapy
Continuous renal replacement
Intermittent hemodialysis
Peritoneal dialysis
Hepatic impairment
Child-Pugh A (mild)
Child-Pugh B (moderate)
Child-Pugh C (severe)
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B3
Breastfeeding
Use only if benefits outweigh potential risks.
Unknown drug levels in breastfed infants.
No overt adverse effects reported in breastfed infants.
Adverse reactions
Common 1-10%
Uncommon < 1%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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