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Emtricitabine / tenofovir disoproxil fumarate

Class
Antiretroviral agents
Subclass
Nucleoside reverse-transcriptase inhibitors
Substance name
Emtricitabine / tenofovir disoproxil fumarate
Contains
Emtricitabine
Tenofovir disoproxil
Common formulations
Film-coated tablet
See also
Emtricitabine / tenofovir alafenamide (Descovy®)
Indications for use
Labeled indications
Adults
Prevention of HIV-1 infection (pre-exposure prophylaxis)
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B3, B3
Use only if benefits outweigh potential risks. Monitor CD4 counts. Monitor plasma HIV RNA. Viral load should be assessed. Perform standard glucose screening. First trimestar ultrasound for gestational age. A second trimester ultrasound can be used for both anatomical survey and determination of gestational age. Antiretroviral therapy should be provided to all patients during pregnancy, regardless of HIV RNA concentrations or CD4 cell count. Using highly active antiretroviral combination therapy (HAART) to maximally suppress viral replication is the most effective strategy to prevent the development of resistance and to minimize the risk of perinatal transmission. Begin HAART as soon as pregnancy is recognized, or HIV is diagnosed. HIV guidelines recommend the use of emtricitabine; tenofovir disoproxil fumarate (DF) as a preferred 2-NRTI backbone in patients with HIV who are pregnant or trying to conceive.
Interactions
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