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Dicloxacillin

Class
Antibiotics
Subclass
Penicillins
Substance name
Dicloxacillin sodium
Common formulations
Capsule
Dosage and administration
Adults patients
Impetigo • Off-label
•
250 mg PO QID for 7 days
Lactational mastitis • Off-label
•
500 mg PO QID for 10-14 days
SSTIs • Off-label
•
500 mg PO QID
Other off-label uses
•
Treatment of bite wound infection (animal or human)
•
Treatment of cellulitis
•
Treatment of infective endocarditis
•
Treatment of prosthetic joint infection (in patients who need chronic suppression therapy)
•
Adjunctive treatment for prosthetic joint infection
Indications for use
Labeled indications
Adults
•
Treatment of staphylococcal infection
•
Treatment of staphylococcal infection (severe)
Off-label indications
Adults
•
Treatment of bite wound infection (animal or human)
•
Treatment of cellulitis
•
Treatment of impetigo
•
Treatment of infective endocarditis
•
Treatment of lactational mastitis
•
Treatment of prosthetic joint infection (in patients who need chronic suppression therapy)
•
Treatment of SSTIs
•
Adjunctive treatment for prosthetic joint infection
Safety risks
Contraindications
Hypersensitivity to dicloxacillin sodium, to any of the penicillins or any component of the formulations
Warnings and precautions
C. difficile colitis, diarrhea
•
Maintain a high level of suspicion, as Clostridium difficile associated diarrhea is reported with use of dicloxacillin sodium, and may present as mild diarrhea to more severe colitis.
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
•
No guidance available.
Renal replacement therapy
Any modality
•
No guidance available.
Hepatic impairment
Any severity
•
Use acceptable. No dose adjustment required.
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B2
•
Generally acceptable for use.
Breastfeeding
Acceptable for use during breastfeeding.
Unknown drug levels in breastfed infants.
Adverse reactions
Common 1-10%
•
Agranulocytosis, allergic reactions, ↓ blood neutrophil count, exfoliative dermatitis, ↑ urine protein, interstitial nephritis, arthralgia, diarrhea, epigastric abdominal pain, hematuria, malaise, myalgia, nausea, vomiting, Stevens-Johnson syndrome, toxic epidermal necrolysis
Uncommon < 1%
•
Angioedema, bronchospasm
Rare < 0.1%
•
Anaphylaxis
Unknown frequency
•
AKI, Clostridioides difficile infection, colitis, ↓ serum potassium, drug-induced liver injury, hemolytic anemia, ↑ LFTs, black hairy tongue, fever, seizure, stomatitis, stomatitis, esophagitis, esophagitis/esophageal ulcer, urticaria
Interactions
Drug(s)
Check Interactions
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