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Calcipotriene

Class
Vitamin D analogs
Subclass
Vitamin D analogs
Substance name
Calcipotriene, calcipotriol
Common formulations
Cream, Ointment
Contained in
Calcipotriene / betamethasone
Dosage and administration
Adults patients
Treatment of plaque psoriasis
•
0.005% TOP BID for 8 weeks
Indications for use
Labeled indications
Adults
•
Treatment of plaque psoriasis
Children
•
Treatment of plaque psoriasis
Safety risks
Contraindications
Hypersensitivity to calcipotriene or its components
•
Conduct patch testing before full application and avoid its use in patients with known hypersensitivity to the drug.
Accidental exposure to unaffected areas of skin
•
Apply the medication only to affected areas as directed, and educate patients on proper application techniques.
Evident hypercalcemia or hypervitaminosis D
•
Mitigate nephrolithiasis risk when using Calcipotriene by carefully assessing calcium and vitamin D levels, and avoiding its use in patients with hypercalcemia or hypervitaminosis D.
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B1
•
Use only if benefits outweigh potential risks. Evidence of fetal harm in animals.
Breastfeeding
Unlikely to have adverse effects in breastfed infants.
Unlikely excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Very common > 10%
•
Burning sensation, generalized pruritus, skin rash
Common 1-10%
•
Application site reactions, dermatitis, dry skin patches, plaque psoriasis, skin erythema
Unknown frequency
•
Contact dermatitis, hyperpigmentation, ↑ serum calcium, ↑ urine calcium
Interactions
Drug(s)
Check Interactions
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