Bupropion hydrochloride XL
Class
Antidepressants
Subclass
Norepinephrine-dopamine reuptake inhibitors
Substance name
buPROPion XL
Brand names
Forfivo XL®, Wellbutrin XL®
Common formulations
Film-coated tablet, Tablet
See also
Bupropion hydrochloride
Bupropion hydrochloride SR (Wellbutrin SR®, Zyban®)
Bupropion hydrobromide ER (Aplenzin®)
Contained in
Naltrexone / bupropion XR (Contrave ER®)
Dosage and administration
Adults patients
Major depressive disorder
Seasonal affective disorder
ADHD • Off-label
Other off-label uses
Indications for use
Labeled indications
Adults
Off-label indications
Adults
Safety risks
Boxed warnings
Suicidal ideation
Contraindications
Hypersensitivity to bupropion or its components
Abrupt discontinuation of alcohol, benzodiazepines, barbiturates, or antiepileptic drugs
Concomitant use of MAOIs
Warnings and precautions
Acute angle-closure glaucoma
Hypertension
Manic or mixed episodes
Psychosis, neuropsychiatric adverse events
Seizure
Specific populations
Renal impairment
GFR 0-90 mL/min
Renal replacement therapy
Intermittent hemodialysis
Peritoneal dialysis
Hepatic impairment
Child-Pugh A (mild)
Child-Pugh B (moderate)
Child-Pugh C (severe)
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B2
Breastfeeding
Consider alternative agents that may be safer.
Very low levels in breastfed infants (< 5%).
May potentially cause adverse effects in breastfed infants.
Some adverse effects on lactation reported.
Adverse reactions
Very common > 10%
Common 1-10%
Uncommon < 1%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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