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Bacitracin / neomycin / polymyxin B

Ophthalmic
Topical
Class
Antibiotics
Subclass
Polypeptide / aminoglycoside / polymixin combination
Substance name
Bacitracin / neomycin / polymyxin B
Brand names
Medi-First®, Neosporin Original®, Triple Antibiotic®
Contains
Bacitracin
Neomycin
Polymyxin
Dosage and administration
Adults patients
Treatment of superficial ocular infections
•
1 ribbon(s) OPHTH q6-8h for 7 to 10 days
Indications for use
Labeled indications
Adults
•
Treatment of superficial ocular infections
Safety risks
Contraindications
Hypersensitivity to bacitracin zinc / neomycin sulfate / polymyxin B sulfate or any of its components
Warnings and precautions
Skin rash, skin erythema
•
Maintain a high level of suspicion as, antibiotics, particularly neomycin sulfate, may cause cutaneous sensitization.
Superinfection
•
Maintain a high level of suspicion, as prolonged use of bacitracin zinc / neomycin sulfate / polymyxin B sulfate may result in overgrowth of non-susceptible organisms particularly fungi.
Specific populations
Renal impairment
eGFR 0-90 mL/min/1.73 m²
•
No guidance available.
Renal replacement therapy
Any modality
•
No guidance available.
Hepatic impairment
Any severity
•
No guidance available.
Pregnancy and breastfeeding
Pregnancy
All trimesters
•
Use only if clearly needed.
Breastfeeding
Use with caution during breastfeeding.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Unknown frequency
•
Allergic contact dermatitis, allergic reactions, anaphylaxis, corneal pathology, eczema, superinfection
Interactions
Drug(s)
Check Interactions
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