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Alogliptin

Class
Hypoglycemic agents
Subclass
Dipeptidyl peptidase-4 inhibitors
Substance name
Alogliptin
Brand names
Nesina®
Common formulations
Film-coated tablet
Contained in
Alogliptin / metformin (Kazano®)
Alogliptin / pioglitazone (Oseni®)
Dosage and administration
Adults patients
Treatment of diabetes mellitus type 2
•
25 mg PO daily
Indications for use
Labeled indications
Adults
•
Treatment of diabetes mellitus type 2
Safety risks
Contraindications
Hypersensitivity to alogliptin
Warnings and precautions
Anaphylaxis
•
Use caution history of angioedema or anaphylaxis to another DPP4 inhibitor.
HF
•
Use caution history of or having risk factors for cardiac disease.
Reactivation of acute pancreatitis
•
Use caution history of pancreatitis.
Specific populations
Renal impairment
eGFR 30-50 mL/min/1.73 m²
•
Maximal dose of 12.5 mg.
eGFR 10-30 mL/min/1.73 m²
•
Maximal dose of 6.25 mg.
eGFR < 10 mL/min/1.73 m²
•
Maximal dose of 6.25 mg.
Renal replacement therapy
Continuous renal replacement
•
Reduce dose. Dose as in eGFR 10-30 mL/min/1.73 m². Maximal dose of 6.25 mg.
Intermittent hemodialysis
•
Reduce dose. Dose as in eGFR < 10 mL/min/1.73 m². Maximal dose of 6.25 mg.
Peritoneal dialysis
•
Reduce dose. Dose as in eGFR < 10 mL/min/1.73 m². Maximal dose of 6.25 mg.
Hepatic impairment
Child-Pugh A (mild)
•
Use acceptable. No dose adjustment required. Monitor serum aminotransferases.
Child-Pugh B (moderate)
•
Use acceptable. No dose adjustment required. Monitor serum aminotransferases.
Child-Pugh C (severe)
•
Use with caution. Monitor serum aminotransferases.
Unexplained abnormality in LFTs
•
Use with caution. Monitor serum aminotransferases.
Pregnancy and breastfeeding
Pregnancy
All trimesters
•
Use only if benefits outweigh potential risks.
Breastfeeding
Little information available on breastfeeding safety.
Unknown amount excreted in breastmilk.
Unknown drug levels in breastfed infants.
Adverse reactions
Very common > 10%
•
Chronic kidney disease, ↓ GFR
Common 1-10%
•
↓ GFR, ↓ GFR, ↓ blood glucose, nasopharyngitis, renal failure, headache, upper respiratory tract infections
Uncommon < 1%
•
Acute pancreatitis, angioedema, hypersensitivity reactions, ileus, ↑ liver enzymes, constipation, diarrhea, nausea, skin rash, rhabdomyolysis, Stevens-Johnson syndrome, tubulointerstitial nephritis and uveitis
Interactions
Drug(s)
Check Interactions
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