Allopurinol
Oral
Intravenous
Class
Urate-lowering agents
Subclass
Xanthine oxidase inhibitors
Substance name
Allopurinol
Brand names
Zyloprim®
Common formulations
Tablet
Dosage and administration
Adults patients
Treatment
Gout • Mild
Gout • Moderate-to-severe
Nephrolithiasis in patients with hyperuricosuria • Recurrent, due to calcium oxalate stones
Prevention
Prevention of chemotherapy-induced hyperuricemia in patients with malignancies
Indications for use
Labeled indications
Adults
Safety risks
Contraindications
Hypersensitivity to allopurinol or its components
HLA-B*58:01 allele carriers
Warnings and precautions
AKI
Drug hypersensitivity reaction
Gout flares
Increased serum transaminases, increased serum ALP
Myelosuppression
Skin rash
Somnolence
Specific populations
Renal impairment
CrCl > 20 mL/min
CrCl 10-20 mL/min
CrCl < 10 mL/min
Renal replacement therapy
Continuous renal replacement
Intermittent hemodialysis
Peritoneal dialysis
Hepatic impairment
Any severity
Pregnancy and breastfeeding
Pregnancy
All trimesters • Australia Category: B2
Breastfeeding
Use only if benefits outweigh potential risks.
Low-moderate levels in breastfed infants (25-45%).
No overt adverse effects reported in breastfed infants.
Adverse reactions
Common 1-10%
Uncommon < 1%
Unknown frequency
Interactions
Drug(s)
Check Interactions
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