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Vasospastic angina

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Updated 2024 ESC guidelines for the management of vasospastic angina.

Guidelines

Key sources

The following summarized guidelines for the evaluation and management of vasospastic angina are prepared by our editorial team based on guidelines from the European Society of Cardiology (ESC 2024,2021), the Japanese College of Cardiology (JCC/CVIT/JCS 2023), and the American Heart Association (AHA/ACC 2014).
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Diagnostic investigations

ECG monitoring
As per ESC 2024 guidelines:
Obtain a resting 12-lead ECG recording during angina in patients with suspected vasospastic angina.
B
Consider obtaining ambulatory ST-segment monitoring to identify ST-segment deviation during angina in patients with suspected vasospastic angina and frequent symptoms.
C
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  • Coronary flow reserve assessment

  • Coronary CTA

  • Cardiac MRI

  • Cardiac PET

  • Cardiac scintigraphy

  • Vascular endothelial function testing

Diagnostic procedures

Coronary angiography: as per ACC/AHA 2014 guidelines, obtain coronary angiography (invasive or noninvasive) in patients with episodic chest pain accompanied by transient ST-segment elevation to rule out severe obstructive coronary artery disease.
B

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  • Coronary provocative testing (general indications)

  • Coronary provocative testing (ischemia with nonobstructive coronary arteries)

  • Coronary provocative testing (myocardial infarction with nonobstructive coronary arteries)

  • Coronary provocative testing (post-PCI)

  • Intravascular ultrasound/optical coherence tomography

Medical management

CCBs: as per ESC 2024 guidelines, initiate CCBs to control symptoms and to prevent ischemia and potentially fatal complications in patients with isolated vasospastic angina.
A

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  • Nitrates

  • Beta-blockers

  • Statins

  • Aspirin

Nonpharmacologic interventions

Smoking cessation: as per CVIT/JCC/JCS 2023 guidelines, advise smoking cessation in patients with vasospastic angina.
A

Therapeutic procedures

Intracoronary fasudil administration: as per CVIT/JCC/JCS 2023 guidelines, consider administering intracoronary fasudil in patients with refractory coronary spasm.
C

More topics in this section

  • ICD

Surgical interventions

Stellate ganglion block and/or thoracic sympathectomy: as per CVIT/JCC/JCS 2023 guidelines, consider performing stellate ganglion block and/or thoracic sympathectomy in patients with refractory or severe vasospastic angina.
C

Follow-up and surveillance

Cardiac rehabilitation
As per CVIT/JCC/JCS 2023 guidelines:
Offer comprehensive cardiac rehabilitation after ischemia with nonobstructive coronary arteries in the absence of contraindications.
A
Advise moderate-to-vigorous aerobic exercise (≥ 30 min, at least thrice weekly).
B