Table of contents

HIV-associated malignancies


Key sources

The following summarized guidelines for the evaluation and management of HIV-associated malignancies are prepared by our editorial team based on guidelines from the British HIV Association (BHIVA 2014). ...
Show more

Diagnostic investigations

Evaluation for Kaposi sarcoma
As per BHIVA 2014 guidelines:
Confirm Kaposi sarcoma histologically.
Consider avoiding routine CT scans, bronchoscopy or gastrointestinal endoscopy in the absence of symptoms.
Create free account

More topics in this section

  • Evaluation for Castleman's disease

  • Evaluation for anal cancer

Medical management

HAART: as per BHIVA 2014 guidelines, initiate HAART in all patients diagnosed with Kaposi sarcoma.

More topics in this section

  • Irradiation of blood products

Specific circumstances

Patients with Kaposi's sarcoma: as per BHIVA 2014 guidelines, initiate chemotherapy along with HAART for patients with T1 advanced stage Kaposi's sarcoma.
Show 3 more

More topics in this section

  • Patients with Hodgkin's lymphoma

  • Patients with diffuse large-B cell lymphoma

  • Patients with Burkitt's lymphoma

  • Patients with multicentric Castleman's disease

  • Patients with primary CNS lymphoma

  • Patients with primary effusion lymphoma

  • Patients with plasmablastic lymphoma

  • Patients with relapsed/refractory aggressive lymphoma

  • Patients with anal cancer

  • Patients with CIN and cervical cancer

  • Patients with non-AIDS-defining malignancies

Preventative measures

As per BHIVA 2014 guidelines:
Provide influenza immunization to all patients with HIV-associated malignancies on an annual basis.
Provide pneumococcal immunization and HBV immunization.

More topics in this section

  • Prophylaxis against opportunistic infections

Follow-up and surveillance

Indications for referral to specialized centers: as per BHIVA 2014 guidelines, refer all patients with HIV and malignancy to centers that have developed expertise in the management of these diseases.

More topics in this section

  • Consideration for enrollment in clinical trials

  • Monitoring for patients with Hodgkin's lymphoma

  • Monitoring for patients with multicentric Castleman's disease