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Xerostomia

Key sources
The following summarized guidelines for the management of xerostomia are prepared by our editorial team based on guidelines from the Multinational Association of Supportive Care in Cancer (MASCC/ISOO/ASCO 2021) and the Sjögren's Syndrome Foundation (SSF 2016).
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Guidelines

1.Medical management

Caries prophylaxis: offer topical fluoride in patients withSjögren's disease with dry mouth.
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  • Muscarinic agonists

  • Biologic agents

2.Nonpharmacologic interventions

Salivary substitutes: as per ASCO 2021 guidelines, consider offering topical mucosal lubricants or saliva substitutes (agents directed at ameliorating xerostomia and other salivary gland hypofunction-related symptoms) to improve xerostomia induced by nonsurgical cancer therapies.
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3.Preventative measures

Prevention of radiation-induced xerostomia: use intensity-modulated radiotherapy to spare major and minor salivary glands from a higher dose of radiation to reduce the risk of salivary gland hypofunction and xerostomia in patients with head and neck cancer.
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