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Lynch syndrome

Key sources
The following summarized guidelines for the evaluation and management of lynch syndrome are prepared by our editorial team based on guidelines from the American Gastroenterological Association (AGA 2015).
1

Guidelines

1.Screening and diagnosis

Case finding: test the tumors of all patients with CRC for MSI to identify potential cases of Lynch syndrome.
B
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2.Classification and risk stratification

Risk prediction: consider using risk prediction models as a first-line assessment, rather than proceeding directly with germline genetic testing, in patients without a personal history of colorectal or another cancer but with a family history suggestive of Lynch syndrome.
C

3.Diagnostic investigations

Surveillance colonoscopy
Obtain surveillance colonoscopy in persons with Lynch syndrome.
B
Consider surveillance colonoscopy every 1 to 2 years versus less frequent intervals.
C

4.Medical management

Aspirin for cancer prevention: consider offering aspirin for cancer prevention in patients with Lynch syndrome.
C