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Lynch syndrome

Guidelines

Key sources

The following summarized guidelines for the evaluation and management of Lynch syndrome are prepared by our editorial team based on guidelines from the American Gastroenterological Association (AGA 2015)....
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Screening and diagnosis

Case finding: as per AGA 2015 guidelines, Test the tumors of all patients with CRC for MSI to identify potential cases of Lynch syndrome.
B
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Classification and risk stratification

Risk prediction: as per AGA 2015 guidelines, Consider using risk prediction models as a first-line assessment, rather than proceeding directly with germline genetic testing, in patients without a personal history of colorectal or another cancer but with a family history suggestive of Lynch syndrome.
C

Diagnostic investigations

Surveillance colonoscopy
As per AGA 2015 guidelines:
Obtain surveillance colonoscopy in persons with Lynch syndrome.
B
Consider surveillance colonoscopy every 1 to 2 years versus less frequent intervals.
C

Medical management

Aspirin for cancer prevention: as per AGA 2015 guidelines, Consider offering aspirin for cancer prevention in patients with Lynch syndrome.
C