Table of contents
Expand All Topics
Dysmetabolic hyperferritinemia
Guidelines
Key sources
The following summarized guidelines for the evaluation and management of dysmetabolic hyperferritinemia are prepared by our editorial team based on guidelines from the Metabolic Hyperferritinemia Consensus Group (MHF-CG 2023) and the American Association for the Study of Liver Diseases (AASLD 2018).
1
2
Screening and diagnosis
Diagnostic criteria
As per MHF-CG 2023 guidelines:
Consider defining the condition of hyperferritinemia related to metabolic dysfunction as metabolic hyperferritinemia. Consider grading the severity of metabolic hyperferritinemia according to serum levels of ferritin thresholds (grades 1-3).
C
Consider defining dysmetabolic iron overload syndrome as increased hepatic iron stores in patients with metabolic hyperferritinemia.
C
Classification and risk stratification
Risk factors
As per MHF-CG 2023 guidelines:
Recognize that insulin resistance and features of metabolic dysfunction are associated with specific alterations of iron metabolism regulation, which are epidemiologically linked with organ damage and clinical outcomes.
B
Recognize that the pathophysiology of this alteration of iron metabolism regulation seems to be triggered by lipotoxicity in the presence of permissive environmental and genetic determinants.
B
Diagnostic investigations
Serum ferritin levels
As per MHF-CG 2023 guidelines:
Consider measuring serum ferritin levels for noninvasive diagnosis and assessment of iron metabolism alteration, namely thr metabolic hyperferritinemia, associated with glucose and lipid metabolism dysregulation and with hepatic lipid accumulation.
B
Consider measuring serum ferritin levels after at least 3 months of lifestyle changes, if possible.
C
More topics in this section
MRI
Diagnostic procedures
Medical management
Management of cardiovascular risk factors: as per MHF-CG 2023 guidelines, focus the clinical management on lifestyle factors associated with increased risk of cardiometabolic risk factors (such as caloric intake and dietary patterns, alcohol intake, fructose and salt intake, and sedentary lifestyle) and the pharmacological control of cardiovascular risk factors.
B
More topics in this section
Iron depletion therapy