Yalcinkaya-Ozen's diagnostic criteria for childhood familial Mediterranean fever

The Yalcinkaya-Ozen's diagnostic criteria is a clinical calculator specifically designed for the diagnosis of Familial Mediterranean Fever (FMF) in children. Familial Mediterranean Fever is a genetic autoinflammatory disorder that causes recurrent fevers and painful inflammation of the abdomen, chest, and joints. This calculator is particularly useful in pediatric populations where FMF is suspected, especially in regions where the disease is prevalent such as the Mediterranean region. The Yalcinkaya-Ozen's diagnostic criteria includes parameters such as typical clinical symptoms, response to colchicine treatment, and presence of MEFV mutations. It helps clinicians to establish a diagnosis of FMF, particularly in cases where genetic testing is not available or inconclusive. The exclusion criteria for the use of this calculator would be the presence of other diseases that can mimic FMF symptoms, such as infections, malignancies, or other rheumatic diseases. Also, it may not be as applicable in populations where FMF is rare.

Reference

Fatos Yalçinkaya, Seza Ozen, Zeynep Birsin Ozçakar et al. A new set of criteria for the diagnosis of familial Mediterranean fever in childhood. Rheumatology (Oxford). 2009 Apr;48(4):395-8.