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TNM classification for parathyroid carcinoma (AJCC)

Tumor classification
Tx: Primary tumor cannot be assessed
T0: No evidence of primary tumor
Tis: Atypical parathyroid neoplasm (neoplasm of uncertain malignant potential)
T1: Localized to the parathyroid gland with extension limited to soft tissue
T2: Direct invasion into the thyroid gland
T3: Direct invasion into the recurrent laryngeal nerve, esophagus, trachea, skeletal muscle, adjacent lymph nodes, or thymus
T4: Direct invasion into major blood vessels or spine
Lymph node classification
Nx: Regional lymph nodes cannot be assessed
N0: No regional lymph node metastasis
N1a: Metastasis to level VI (pretracheal, paratracheal, and prelaryngeal/Delphian lymph nodes) or superior mediastinal lymph nodes (level VII)
N1b: Metastasis to unilateral, bilateral, or contralateral cervical (level I, II, III, IV, or V) or retropharyngeal nodes
Metastasis classification
M0: No distant metastasis
M1: Distant metastasis present
The AJCC does not provide anatomic stage and prognostic groups for parathyroid carcinoma due to insufficient data.
Reference
Amin, M.B., Edge et al. AJCC Cancer Staging Manual. AJCC. 2017.
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