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TNM classification for gastric cancer

Tumor classification
Tx: Primary tumor cannot be assessed
T0: No evidence of primary tumor
Tis: High-grade dysplasia/carcinoma in situ
T1a: Tumor invades lamina propria or muscularis mucosae
T1b: Tumor invades submucosa
T2: Tumor invades muscularis propria
T3: Tumor invades subserosal connective tissue without invasion of visceral peritoneum or adjacent structures (spleen, transverse colon, liver, diaphragm, pancreas, abdominal wall, adrenal gland, kidney, small intestine, or retroperitoneum); intramural extension to duodenum or esophagus is not considered as invasion to an adjacent structure, but is classified by the depth of greatest invasion in any of these sites; tumor may penetrate muscularis propria with extension into gastrocolic or gastrohepatic ligaments, or into the greater or lesser omentum, without perforation of visceral peritoneum covering these structures
T4a: Tumor invades visceral peritoneum
T4b: Tumor invades adjacent structures/organs (spleen, transverse colon, liver, diaphragm, pancreas, abdominal wall, adrenal gland, kidney, small intestine, or retroperitoneum)
Lymph node classification
Nx: Regional lymph nodes cannot be assessed
N0: No regional lymph node metastasis
N1: 1-2 regional lymph nodes metastases
N2: 3-6 regional lymph nodes metastases
N3a: 7-15 regional lymph nodes metastases
N3b: ≥ 16 regional lymph nodes metastases
Distant metastasis
M0: No distant metastasis
M1: Distant metastasis present
Stage cannot be fully assessed
Reference
Amin, M.B., Edge et al. AJCC Cancer Staging Manual. AJCC. 2017.
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