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TNM classification for gallbladder cancer

Tumor classification
Tx: Primary tumor cannot be assessed
T0: No evidence of primary tumor
Tis: Carcinoma in situ
T1a: Tumor invading lamina propria
T1b: Tumor invading muscular layer
T2a: Tumor invading perimuscular connective tissue on peritoneal side, without involvement of serosa (visceral peritoneum)
T2b: Tumor invading perimuscular connective tissue on hepatic side, with no extension into liver
T3: Tumor perforating serosa (visceral peritoneum) and/or directly invading liver and/or one other adjacent organ or structure (such as stomach, duodenum, colon, pancreas, omentum, or extrahepatic bile ducts)
T4: Tumor invading main portal vein or hepatic artery or invading ≥ 2 extrahepatic organs or structures
Lymph node classification
Nx: Regional lymph nodes cannot be assessed
N0: No regional lymph node metastasis
N1: Metastases to 1-3 regional lymph nodes
N2: Metastases to ≥ 4 regional lymph nodes
Metastasis classification
M0: No distant metastasis
M1: Distant metastasis present
Stage cannot be fully assessed
Reference
Amin, M.B., Edge et al. AJCC Cancer Staging Manual. AJCC. 2017.
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