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TNM classification for appendiceal neuroendocrine tumors

Tumor classification
Tx: Primary tumor cannot be assessed
T0: No evidence of primary tumor
T1: Tumor ≤ 2 cm in greatest dimension
T2: Tumor > 2 cm but ≤ 4 cm
T3: Tumor > 4 cm or with subserosal invasion or involvement of the mesoappendix
T4: Tumor perforates the peritoneum or directly invades other adjacent organs or structures (excluding direct mural extension to adjacent subserosa of adjacent bowel), such as abdominal wall and skeletal muscle
Lymph node classification
Nx: Regional lymph nodes cannot be assessed
N0: No regional lymph node metastasis
N1: Regional lymph node metastasis present
Distant metastasis
M0: No distant metastasis
M1: Distant metastasis
M1a: Metastasis confined to liver
M1b: Metastasis in at least one extrahepatic site (lung, ovary, nonregional lymph node, peritoneum, bone)
M1c: Both hepatic and extrahepatic metastases
Stage cannot be fully assessed
Reference
Manisha H Shah, Whitney S Goldner, Al B Benson et al. Neuroendocrine and Adrenal Tumors, Version 3.2021, NCCN Clinical Practice Guidelines in Oncology. NCCN. 2021 Aug 13.
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