The Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) offers insights into an individual's insulin sensitivity using two key measurements: fasting glucose and fasting insulin levels. These inputs are required to evaluate insulin resistance and can be provided in different units. 

For fasting glucose, you can use:
- mg/dL, with a range from 50 to 400
- mmol/L, with a range from 2.78 to 22.2

For fasting insulin, the options are:
- uIU/mL, with a range from 1 to 100
- pmol/L, with a range from 6 to 600

If the measurements are given in mmol/L or pmol/L, conversions will be necessary. Convert fasting glucose from mmol/L to mg/dL by multiplying by 18.0182. For insulin, convert from pmol/L to uIU/mL by dividing by 6.

After standardizing the units, the HOMA-IR score is calculated using the formula:

HOMA-IR Score = (fasting insulin in uIU/mL * fasting glucose in mg/dL) / 405

The result, rounded to two decimal places, determines the level of insulin resistance:

- Scores less than 1 indicate normal insulin sensitivity.
- Scores from 1 to just under 2 suggest mild insulin resistance.
- Scores from 2 to just under 3 imply moderate insulin resistance.
- Scores of 3 or more reflect severe insulin resistance.

These interpretations help contextualize how the body's insulin management might be impacting health, signaling the potential risk for conditions associated with insulin resistance.

The Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) estimates insulin resistance based on fasting plasma glucose and fasting plasma insulin levels. It is widely used to assess metabolic health, particularly in studies of type 2 diabetes and metabolic syndrome.