The MASCC scoring system for febrile neutropenia is a tool that calculates a numerical score to help estimate the risk of serious complications in patients based on seven key clinical criteria. Each criterion is associated with specific conditions that contribute a designated number of points to the overall score. Below is a concise explanation of how each criterion can affect the scoring:

- Burden of Illness:
  - None or mild symptoms score 5 points.
  - Moderate symptoms score 3 points.
  - Severe symptoms score 0 points.

- Hypotension (systolic blood pressure < 90 mmHg):
  - No hypotension grants 5 points.
  - Presence of hypotension scores 0 points.

- Active Chronic Obstructive Pulmonary Disease (COPD):
  - Absence of COPD gains 4 points.
  - Presence of COPD scores 0 points.

- Type of Cancer:
  - Patients with a solid tumor score 4 points.
  - Hematologic cancer without prior fungal infection scores 4 points.
  - Hematologic cancer with prior fungal infection scores 0 points.

- Dehydration requiring IV fluids:
  - Lack of dehydration grants 3 points.
  - Dehydration scores 0 points.

- Status at Fever Onset:
  - Being an outpatient scores 3 points.
  - Being an inpatient scores 0 points.

- Age, years:
  - Patients younger than 60 score 2 points.
  - Patients aged 60 or older score 0 points.

The total score is the sum of points from these criteria, providing a range between 0 and 26. This total determines the patient's interpretation of risk:

- A score of 21 or more suggests that the risk of serious complications is low.
- Any score below 21 indicates a high risk of serious complications. 

This systematic scoring aids clinicians in making informed decisions about the treatment and management of patients with febrile neutropenia.

The MASCC Score, or Multinational Association for Supportive Care in Cancer Score, is a clinical calculator used in the management of patients with febrile neutropenia, a common complication in cancer patients undergoing chemotherapy. This scoring system is used to identify low-risk patients who are likely to have a better prognosis and may be candidates for outpatient management. The MASCC Score takes into account factors such as age, history of chronic obstructive pulmonary disease, history of fungal infection, blood pressure, and symptoms like fatigue, dehydration, and oral mucositis. Patients with a MASCC score of 21 or higher are considered low-risk. The calculator should not be used in patients with severe sepsis or septic shock, or in those with other serious medical conditions that require hospitalization.

MASCC Score for Febrile Neutropenia