The International Prognostic Scoring System (IPSS) for Waldenstrom's macroglobulinemia is a clinical calculator used to predict the prognosis of patients diagnosed with Waldenstrom's macroglobulinemia, a rare type of non-Hodgkin lymphoma. The IPSS is based on five factors: age, hemoglobin level, platelet count, beta2-microglobulin level, and monoclonal IgM concentration. Each factor is assigned a score, and the total score is used to classify patients into risk groups (low, intermediate, and high), which can guide treatment decisions and provide information about the patient's expected survival. The IPSS is not applicable to patients with other types of lymphoma or to those who have already received treatment for Waldenstrom's macroglobulinemia.

International Prognostic Scoring System (IPSS) for Waldenstrom's macroglobulinemia

# Description:
The International Prognostic Scoring System (IPSS) for Waldenstrom's macroglobulinemia is a clinical calculator used to predict the prognosis of patients diagnosed with Waldenstrom's macroglobulinemia, a rare type of non-Hodgkin lymphoma. The IPSS is based on five factors: age, hemoglobin level, platelet count, beta2-microglobulin level, and monoclonal IgM concentration. Each factor is assigned a score, and the total score is used to classify patients into risk groups (low, intermediate, and high), which can guide treatment decisions and provide information about the patient's expected survival. The IPSS is not applicable to patients with other types of lymphoma or to those who have already received treatment for Waldenstrom's macroglobulinemia.
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# Inputs:
A. Age > 65 years
B. Hemoglobin <= 11.5 g/dL
C. Platelet count <= 100×10**9/L
D. Serum beta2-microglobulin > 3 mg/L
E. Monoclonal IgM concentration > 70 g/L
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# Scoring:
- If (A and B and C) or (A and B and D) or (A and B and E) or (A and C and D) or (A and C and E) or (A and D and E) or (B and C and D) or (B and C and E) or (B and D and E) or (C and D and E), then 5-year survival is 36%
- If A or ((B and C) or (B and D) or (B and E) or (C and D) or (C and E) or (D and E)), then 5-year survival is 68%
- If true, then 5-year survival is 87%)