The Dynamic International Prognostic Scoring System (DIPSS) is a clinical calculator specifically designed for patients with primary myelofibrosis, a rare bone marrow disorder that disrupts the body's normal production of blood cells. The DIPSS is used to stratify patients into risk groups (low, intermediate-1, intermediate-2, and high risk) based on various clinical parameters including age, hemoglobin level, white blood cell count, percentage of blasts in peripheral blood, and presence of constitutional symptoms. 

The clinical utility of the DIPSS lies in its ability to predict survival outcomes and guide therapeutic decisions in patients with primary myelofibrosis. It helps clinicians to tailor treatment strategies according to the risk category of the patient, thereby improving patient management and potentially extending survival. 

There are no specific exclusion criteria for the use of the DIPSS. However, it should be noted that this scoring system is not applicable to patients with secondary myelofibrosis or other types of myeloproliferative disorders.

Dynamic International Prognostic Scoring System (DIPSS) for myelofibrosis

# Criteria
 ## Age, years
A. <= 65 (+0)
B. > 65 (+1)
## White blood cell count, cells/mm**3
C. <= 25,000 (+0)
D. > 25,000 (+1)
## Hemoglobin, g/dL
E. >= 10 (+0)
F. < 10 (+2)
## Peripheral blood blasts
G. < 1% (+0)
H. >= 1% (+1)
## Constitutional symptoms
I. Yes (+1)
J. No (+0)

# Conditions
- score == 0
- score <= 2
- score <= 4
- score <= 6

A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment).