The calculator in question is the Dutch Lipid Clinic Network (DLCN) criteria for Familial Hypercholesterolemia (FH). This scoring system is used to diagnose patients with familial hypercholesterolemia, a genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein (LDL), in the blood and early cardiovascular disease.

The DLCN criteria for FH is a comprehensive scoring system that takes into account the patient's personal and family history of premature coronary artery disease, LDL cholesterol levels, presence of physical signs related to high cholesterol (such as tendon xanthomas), and genetic testing results. 

The clinical utility of this calculator is to aid in the diagnosis of FH, which can be challenging due to the wide range of phenotypic expressions. Early diagnosis of FH is crucial as it allows for prompt initiation of lipid-lowering therapy to reduce the risk of atherosclerotic cardiovascular disease.

There are no specific exclusion criteria for the use of the DLCN criteria. However, it should be noted that this scoring system is less useful in populations with a high prevalence of polygenic hypercholesterolemia or in individuals with secondary causes of hypercholesterolemia, as it may overestimate the likelihood of

DLCN criteria for familial hypercholesterolemia

# Criteria
 ## Family history
A. First-degree relative with known premature coronary or vascular disease (males < 55 years old; females < 60 years old) or a first-degree relative with known LDL-C above the 95th percentile (+1)
B. First-degree relative with tendinous xanthomata and/or arcus cornealis, or children < 18 years old with LDL-C above the 95th percentile (+2)
## Clinical history
C. Patient with premature CAD (males < 55 years old; females < 60 years old) (+2)
D. Patient with premature cerebral or peripheral vascular disease (males < 55 years old; females < 60 years old) (+1)
## Physical examination
E. Tendinous xanthomata (+6)
F. Arcus cornealis before age 45 years (+4)
## LDL-C levels (without treatment)
G. LDL-C >= 8.5 mmol/L [>= 325 mg/dL] (+8)
H. LDL-C 6.5-8.4 mmol/L [251-325 mg/dL] (+5)
I. LDL-C 5.0-6.4 mmol/L [191-250 mg/dL] (+3)
J. LDL-C 4.0-4.9 mmol/L [155-190 mg/dL] (+1)
## DNA analysis
K. Functional mutation in the LDLR, apoB, or PCSK9 genes (+8)

# Conditions
- score > 8
- score >= 6
- score >= 3
- true
- score == 0