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Someone asked:

What are the criteria to screen for ovarian cancer?

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Pathway AI answered:

  • There are no universally accepted criteria for screening for ovarian cancer.

  • The two main screening methods are transvaginal ultrasound and the measurement of serum tumor markers, specifically CA-125
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  • These methods are typically used in women with a high genetic risk due to inherited gene mutations (BRCA1/2) or a strong family history .
  • For instance, ESMO 2016 guidelines recommend obtaining transvaginal ultrasound and serum CA-125 every 6 months starting at the age of 30 in BRCA mutation carriers, until risk-reducing salpingo-oophorectomy .
  • Similarly, ACOG/SGO 2017 guidelines suggest screening transvaginal ultrasound or serum CA-125 for short-term surveillance in patients at high risk of ovarian cancer, starting at age 30-35 years until risk-reducing bilateral salpingo-oophorectomy .

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Indications for screening, general population (ACOG)
Recommendation

Ovarian cancer

ACOG 2017 guidelines recommend to insufficient evidence to recommend obtaining transvaginal ultrasound and tumor markers, such as CA-125, alone or in combination, for early detection of OC in average-...
Pathway Strong recommendation